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Overhead photo of chicken spinach lasagna on a white plate next to a casserole dish of lasagna and a pink cloth. There is also a fork and a knife on the white wooden table.

Chicken Spinach Lasagna

Bethany Galloway
This protein-packed White Chicken Spinach Lasagna is hearty, creamy, and full of flavor. It’s layered with juicy chicken, creamy Alfredo sauce, and a rich spinach-cheese filling for a hearty meal that satisfies the whole family. Perfect for dinner or meal prep for the week!
Prep Time 15 minutes
Cook Time 45 minutes
Resting Time 10 minutes
Total Time 1 hour 10 minutes
Course Main Course
Servings 9 Servings
Calories 470
Protein 42

Ingredients

  • 3 cups cooked chicken shredded - I made instant pot shredded chicken, rotisserie chicken is great too, about 1lb or 450g
  • 12 lasagna noodles
  • 1 cup shredded mozzarella cheese - 100g
  • 1/4 cup grated parmesan

Cheese Mixture

  • cups cottage cheese - 600g
  • 1/2 cup grated parmesan cheese - 60g
  • 1/3 cup egg whites - 2 eggs, 77g
  • 2 teaspoons garlic powder
  • 2 teaspoons Italian seasoning
  • 1 teaspoon kosher salt
  • ½ teaspoon black pepper
  • 2 cups shredded mozzarella cheese - 200g
  • 8 oz frozen spinach - thawed and excess liquid squeezed out, 227g

Cottage Cheese Alfredo Sauce

  • 1 cup cottage cheese - I use nonfat but 2% or 4% works too, 240g
  • 1 tablespoon butter
  • 3 garlic cloves minced
  • 1/4 cup parmesan cheese grated
  • 1/2 teaspoon ground black pepper
  • 1/2 cup protein milk chilled - fairlife or arla bob skimmed
  • 1/2 teaspoon salt

Garnish

  • 2 tablespoons fresh parsley chopped - to garnish
  • red pepper flakes

Instructions

  • Start by thawing and draining the spinach. I used the defrost setting on my microwave for about 3 minutes, and then squeezed it in a fine mesh sieve over the sink.
  • Preheat your oven to 375°F. Move the rack to the top third of the oven.

Make the spinach cheese mixture:

  • Blend the cottage cheese, parmesan, and egg whites together until smooth.
  • Mix the cottage cheese mixture with spinach, mozzarella, garlic powder, Italian seasoning, salt, and pepper until well combined. Set aside.

Make the cottage cheese alfredo sauce:

  • Add the butter and garlic to a small bowl, and microwave them for about a minute, until the butter is melted and bubbling slightly.
  • Add the warmed butter and garlic, cottage cheese, parmesan cheese, pepper, and milk to a large bowl or blender and blend well, until smooth - about 2 minutes. I used an immersion blender.

To assemble the lasagna:

  • Spread 1/4 cup of the cottage cheese alfredo sauce on the bottom of a deep 9×13 casserole dish.
  • Layer 1: Add 4 lasagna noodles to the bottom of the casserole dish. It's okay if they overlap. Spread 1/2 of the cheese spinach mixture over top, add 1/2 the chicken, and then spoon 1/3 of the cottage cheese alfredo sauce on top of that.
  • Layer 2: Add another 4 lasagna noodles, the rest of the cheese mixture, the rest of the chicken, another 1/3 of the cottage cheese alfredo sauce.
  • Layer 3: Add the final layer of 4 lasagna noodles. Spread on the rest of the cottage cheese alfredo sauce, then top with the remaining cup of mozzarella cheese.
  • Cover with foil and bake for 30 minutes, then uncover and continue baking for another 15 minutes. If needed, broil for a few minutes until the cheese is browned (watch it carefully).
  • Let the lasagna sit for 10 minutes before slicing. Use a sharp knife to slice it into squares and then serve each piece with a flat spatula. Season with extra salt & pepper if desired, a dash of red chili flakes for some heat, and chopped parsley for a pop of herby freshness.

Notes

  • Noodles: Use al dente noodles if boiling; they’ll finish cooking in the oven.
  • Creamier: To make it creamier, you can optionally add 1/2 cup of cream cheese to either the spinach mixture or the alfredo sauce. Adjust the seasoning as needed.
  • Rest: Don’t skip resting time—it helps avoid runny lasagna.
  • Prep like a pro: Make ahead by assembling the lasagna and storing it in the fridge until ready to bake.

Storage instructions

  • Refrigerate: Store leftovers in an airtight container in the fridge for up to 3-4 days.
  • Freeze: Wrap individual portions tightly in plastic wrap, then foil, and freeze for up to 3 months.
  • Reheat: Warm in the oven at 350°F until heated through, or microwave in 1-minute increments, covered with a damp paper towel to retain moisture.

Nutritional Information

Calories: 470kcal | Carbohydrates: 35g | Protein: 42g | Fat: 17g | Saturated Fat: 9g | Polyunsaturated Fat: 1g | Monounsaturated Fat: 5g | Trans Fat: 0.1g | Cholesterol: 81mg | Sodium: 1261mg | Potassium: 454mg | Fiber: 2g | Sugar: 4g | Vitamin A: 3413IU | Vitamin C: 2mg | Calcium: 420mg | Iron: 2mg