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Overhead photo of chicken spinach lasagna on a white plate next to a casserole dish of lasagna and a pink cloth. There is also a fork and a knife on the white wooden table.

Chicken Spinach Lasagna

Bethany Galloway
This protein-packed White Chicken Spinach Lasagna is hearty, creamy, and full of flavor. It’s layered with juicy chicken, creamy Alfredo sauce, and a rich spinach-cheese filling for a hearty meal that satisfies the whole family. Perfect for dinner or meal prep for the week!
Prep Time 15 minutes
Cook Time 45 minutes
Resting Time 10 minutes
Total Time 1 hour 10 minutes
Course Main Course
Servings 9 Servings
Calories 520
Protein 43

Ingredients

  • 3 cups cooked chicken shredded - I made instant pot shredded chicken, rotisserie chicken is great too, about 1lb or 450g
  • 12 lasagna noodles
  • 1 cup shredded mozzarella cheese - 100g
  • ¼ cup parmesan cheese - grated

Cheese Mixture

  • cups cottage cheese - 600g
  • ½ cup parmesan cheese - grated, 60g
  • cup egg whites - from 2 eggs, 77g
  • 2 teaspoons garlic powder
  • 2 teaspoons Italian seasoning
  • 1 teaspoon salt
  • ½ teaspoon ground black pepper
  • 2 cups shredded mozzarella cheese - 200g
  • 8 oz frozen spinach - thawed and excess liquid squeezed out, 227g

Cottage Cheese Alfredo Sauce

  • 1 cup cottage cheese - I use nonfat but 2% or 4% works too, 240g
  • 1 tablespoon butter
  • 3 garlic cloves - minced
  • ¼ cup parmesan cheese - grated
  • 1 cup filtered milk - fairlife or arla bob skimmed
  • ½ cup cream cheese - room temperature
  • ½ teaspoon salt
  • ½ teaspoon ground black pepper

Garnish

  • 2 tablespoons fresh parsley - chopped, to garnish
  • red pepper flakes

Instructions

  • Start by thawing and draining the spinach. I used the defrost setting on my microwave for about 3 minutes, and then squeezed it in a fine mesh sieve over the sink.
    8 oz frozen spinach
  • Preheat your oven to 375°F. Move the rack to the top third of the oven.

Make the spinach cheese mixture:

  • Blend the cottage cheese, parmesan, and egg whites together until smooth.
    2½ cups cottage cheese, ⅓ cup egg whites, ½ cup parmesan cheese
  • Mix the cottage cheese mixture with spinach, mozzarella, garlic powder, Italian seasoning, salt, and pepper until well combined. Set aside.
    2 teaspoons garlic powder, 2 teaspoons Italian seasoning, 1 teaspoon salt, 2 cups shredded mozzarella cheese, ½ teaspoon ground black pepper

Make the cottage cheese alfredo sauce:

  • Add the butter and garlic to a small bowl, and microwave them for about a minute, until the butter is melted and bubbling slightly.
    1 tablespoon butter, 3 garlic cloves
  • Add the warmed butter and garlic, cottage cheese, parmesan cheese, salt, pepper, milk, and cream cheese to a large bowl or blender and blend well, until smooth - about 2 minutes. I used an immersion blender.
    1 cup cottage cheese, ¼ cup parmesan cheese, 1 cup filtered milk, ½ cup cream cheese, ½ teaspoon salt, ½ teaspoon ground black pepper

To assemble the lasagna:

  • Spread 1/4 cup of the cottage cheese alfredo sauce on the bottom of a deep 9×13 casserole dish.
  • Layer 1: Add 4 lasagna noodles to the bottom of the casserole dish. It's okay if they overlap. Spread 1/2 of the cheese spinach mixture over top, add 1/2 the chicken, and then spoon 1/3 of the cottage cheese alfredo sauce on top of that.
    12 lasagna noodles, 3 cups cooked chicken shredded
  • Layer 2: Add another 4 lasagna noodles, the rest of the cheese mixture, the rest of the chicken, another 1/3 of the cottage cheese alfredo sauce.
  • Layer 3: Add the final layer of 4 lasagna noodles. Spread on the rest of the cottage cheese alfredo sauce, then top with the remaining cup of mozzarella cheese and grated parmesan.
    1 cup shredded mozzarella cheese, ¼ cup parmesan cheese
  • Cover with foil and bake for 30 minutes, then uncover and continue baking for another 10 minutes. If needed, broil for a few minutes until the cheese is browned (watch it carefully).
  • Let the lasagna sit for 10 minutes before slicing. Use a sharp knife to slice it into squares and then serve each piece with a flat spatula. Season with extra salt & pepper if desired, a dash of red chili flakes for some heat, and chopped parsley for a pop of herby freshness.
    red pepper flakes, 2 tablespoons fresh parsley

Notes

  • Noodles: Use al dente noodles if boiling; they’ll finish cooking in the oven.
  • Creamier: To make it creamier, you can optionally add 1/2 cup of cream cheese to either the spinach mixture or the alfredo sauce. Adjust the seasoning as needed.
  • Rest: Don’t skip resting time—it helps avoid runny lasagna.
  • Prep like a pro: Make ahead by assembling the lasagna and storing it in the fridge until ready to bake.

Storage instructions

  • Refrigerate: Store leftovers in an airtight container in the fridge for up to 3-4 days.
  • Freeze: Wrap individual portions tightly in plastic wrap, then foil, and freeze for up to 3 months.
  • Reheat: Warm in the oven at 350°F until heated through, or microwave in 1-minute increments, covered with a damp paper towel to retain moisture.

Nutritional Information

Calories: 520kcal | Carbohydrates: 36g | Protein: 43g | Fat: 22g | Saturated Fat: 12g | Polyunsaturated Fat: 2g | Monounsaturated Fat: 6g | Trans Fat: 0.1g | Cholesterol: 94mg | Sodium: 1307mg | Potassium: 498mg | Fiber: 2g | Sugar: 5g | Vitamin A: 3589IU | Vitamin C: 2mg | Calcium: 452mg | Iron: 2mg